We have many excellent workshops planned for SB3C2019. Please see below for details.

Pre-conference Software Workshops

Tuesday, June 25, 9:30AM – 11:30AM, 11:30AM – 1:30PM

Workshop Organizers:Alberto Figueroa, Chris Arthurs

Workshop Description: CRIMSON, the CardiovasculaR Modelling and SimulatiON Environment, is a complete software pipeline for segmenting blood vessels from medical imaging data, generating meshes, designing and specifying boundary conditions and material properties, and performing finite element simulation of blood flow on thousands of CPU cores, using the SUPG-stabilised incompressible Navier-Stokes equations. Upon completing the short course, attendees will have the basic knowledge required for performing image-derived patient-specific simulations of arterial blood flow using CRIMSON in their own research groups. Because of CRIMSON’s focus on presenting cutting-edge modelling and simulation features via a modern and intuitive user interface, complete novices can learn to perform their first segmentation and simulation in a short period of time. The second half or the short course will teach some selected advanced features of CRIMSON, such as custom boundary condition design tools, transitional physiology and cardiovascular control scripting, or PC-MRI boundary condition imposition, depending on the interest of the attendees. Attendees will leave the short course with an in-depth understanding of how CRIMSON can accelerate their own research. Attendees will be required to bring their own laptops and a proper mouse, and should have CRIMSON pre-installed from www.crimson.software.

Workshop speakers: Alberto Figueroa, Chris Arthurs, Sabrina Lynch

Workshop Organizers: Alison Marsden, Stanford University; David Parker, Stanford University; Shawn Shadden, UC Berkeley; Nathan Wilson, Open Source Medical Software Corporation

Workshop Description: SimVascular is the only fully open source software package providing a complete pipeline from medical image data to cardiovascular blood flow simulation results and analysis (www.simvascular.org). It offers capabilities for image segmentation, unstructured adaptive meshing, physiologic boundary conditions, and two Navier-Stokes finite element solvers with fluid structure interaction capabilities, including large deformation motion with an Arbitrary Lagrangian Eulerian (ALE) formulation. An accompanying vascular model repository provides over 100 clinical data sets with simulation results from different parts of the vasculature to enable research. Extensive online documentation and tutorials with clinical examples are provided online. In this workshop, we will interactively take new users through a step-by-step tutorial, covering basic steps of model construction, meshing, flow simulations, and best practices for high quality results. We will also introduce several new features of SimVascular, including a module for image segmentation with machine learning, a python scripting interface, and a pipeline for reduced-order modeling with a 1D solver. Following a series of interactive demonstrations, we will moderate a question and answer session for current and potential users.

Workshops 1

Tuesday June 25, 2:00 – 3:30 PM

Workshop Organizers: Rupak Banerjee

Workshop description: This special workshop/symposium is dedicated to the valuable contributions of Dr. John Pearce to the topic of thermal damage processes in tissues. Motivated by clinical experience in the Department of Surgery at the Medical University of South Carolina in the early 1970s, Dr. Pearce has worked for over 40 years on this topic, form his dissertation on the “The Thermal Performance of Electrosurgical Dispersive Electrodes” to, his 1986 book on Electrosurgery, to the development of the Ligasure vessel sealing system, and more recent work on accurate modeling of intrinsic cell death processes at low temperatures. After 35 years on the faculty of the Electrical and Computer Engineering Department at the University of Texas at Austin he retired as Temple Foundation Professor Emeritus. He is a Fellow of the ASME, and the International Microwave Power Institute.

Potential speakers: John C. Bischof (Keynote), Kenneth Diller (Keynote), Rupak Banerjee,

Workshop Organizers: Mehmet Kurt, Stevens Institute of Technology; Brittany Coats, University of Utah

Workshop Description: Since the onset of medicine, the simplest, most immediate hands-on diagnostic tool has been the test of palpation: variations in the local mechanical properties of tissue can in fact be indicative of a variety of pathologies. Even within modern medicine, this remains a precious way to assess the need of more sophisticated clinical investigations. However, there remain two critical roadblocks in translating imaging methods into clinical practice: 1) How can we palpate and image tissues that are relatively inaccessible and deep within the human body, such as the brain and the liver? 2) How can we bridge the understanding between the tissue-level mechanical properties of the tissues with the underlying cellular mechanics and physiology? In this workshop, we will hear from five researchers who have developed successful mechanical imaging methods that are making an immediate impact in clinical diagnosis and treatment within the context of these two main research challenges. Attendees will learn about various multi-scale mechanical imaging techniques that have already made substantial clinical impact and gain insights into where some of the challenges in the multi-scale mechanical imaging lie.

Format: The format will be five 12-minute presentations from the speakers followed by a 30-minute question/answer session.

Proposed Speakers: MR-based mechanical imaging techniques: Armando Manduca, Mayo Clinic; Deva Chan, Rensselaer Polytechnic Institute; Ultrasound Elastography: Elisa Konofagou, Columbia University; Optical Elastography: Giuliano Scarcelli, University of Maryland at College-Park; Synchrotron Radiation X-ray Scattering: Claire Acevedo, University of Utah.

Workshop Organizers: Sara Wilson, University of Kansas; Michele Grimm, National Science Foundation; Victor Lai, University of Minnesota Duluth; Rouzbeh Amini, University of Akron

Workshop description: Many SB3C attendees are graduate students, post-doctoral trainees, and faculty members who are or will soon be teaching their first classes. Promoting ethical behavior among students and handling disciplinary issues when academic misconduct takes place can be some of the most challenging tasks to be undertaken by a first-time instructor. The purpose of this workshop is to provide an overview of best practices for promoting an honor system among the students, preventing the underlying issues that can lead to academic misconduct, and handling difficult conversations/decisions that result from the violation of such ethical standards. The workshop includes three 20-minute seminars presented by three of our more seasoned colleagues, who will share their experiences and best practices. Time at the end of the workshop will be provided for an open Q & A session and potential input from the audience. The topics of discussion include encouraging students to focus on mastering the material rather than only trying to do well on tests and assignments, adopting methods to increase students’ self-efficacy, developing a reputation for being a “fair professor,” clearly defining academic misconduct, using resources to check for plagiarism, etc. The organizers and presenters expect to prepare a manuscript for submission to the ASME Journal of Biomechanical Engineering Annual Educational issue to further disseminate the information provided in this workshop.

Workshops 2:

Thursday, June 27, 2:00 – 3:30 PM

Workshop organizers: David Pierce, Mariana Kersh, Matthew Fisher

Workshop description: Understanding of the mechanics of both soft and hard tissues has greatly improved over the last few decades. In parallel, recent advances have pushed this understanding to the cellular and subcellular levels. However, the community developed the bulk of this understanding using isolated tissues and cells ex vivo. The interfaces and gradients inherent to many soft tissues are often crucial to their function, e.g. muscle-tendon-bone, cartilage-bone. Moreover, these tissues interact over multiple length scales. This session will focus on such, often understudied, multiscale interfaces, see Figure 1.
The goal of this workshop is to promote cross-fertilization of ideas and collaborative experimental and computational efforts towards more rapid progress in advancing understanding of the multiscale mechanics across interfaces. Therefore, we propose holding this workshop as a joint workshop between the Solid Mechanics and the Cell & Tissue Engineering groups. Important themes include:
Solid Mechanics (Growth, Remodeling and Repair; Injury; Musculoskeletal Soft Tissue Mechanics; Bone Mechanics; Joint and Spine Mechanics; Other Solid Mechanics Topics)
Tissue & Cellular Engineering (Nano, Micro and Multiscale; Tissue Engineered Disease Models; Growth, Remodeling and Repair; Musculoskeletal Tissue Engineering; The Cellular Microenvironment; Mechanotransduction and Sub-cellular Biophysics; Technology for Probing Tissue and Cellular Mechanics; Other – Tissue Engineering, Cellular and Molecular Biomechanics)

Workshop format: 3-4 15 minute invited talks plus 30-45 minutes curated discussion.

Potential speakers: Silvia Blenker, Mariana Kersh, Grace O’Connell, Dawn Elliott, Virginia Ferguson, Sandra Shefelbine

Workshop Organizers: Kristen Billiar

Workshop Description: Track Chairs from the BME Education Summit (May 2019, Cleveland, OH) will provide a summary of the discussion from the sessions at the Summit, and they will solicit additional comments.
Workshop Speakers: Kristen Billiar, Susan Margulies, Bob Tranquillo, and other session organizers

Workshop Organizers: Chiara Bellini and Jessica Oakes (Department of Bioengineering, Northeastern University, Boston, MA)

Workshop Description: Rodent models are often leveraged to gain a better understanding of disease processes, with the ultimate goal of identifying key features for the benefit of human health. This has become even more true as genetically-modified mice have become widely available and technology advancements have made it possible to quantify physiological processes at a small scale. The aim of this workshop is to discuss the pros/cons of working with rodent models and emerging methods on how to link data collected in rodents, or pre-clinical models, to humans. Specifically, we will bring together experts in imaging, mechanics, and predictive modeling to address these challenges and facilitate a discussion over a broad range of disciplines. Each speaker will focus on a different system and/or disease.

Potential speakers: Katherine Zhang, Patrick Segers, Craig Goergen, Naomi Chesler, Jason Bates, Kristin Meyers, Kristin Miller, Louis J. Soslowsky, Sandra Shefelbine

Workshop Organizers: Anita Singh, Widener University; others TBD

Workshop Description: Community-based learning (CBL) holds many benefits for students by: a) enhancing learning within the core content area, b) broadening of professional skills that are needed in today’s global economy, and c) deepening our learning about the communities we live in. Bridging the gap between Science, Technology, Engineering and Mathematics (STEM) disciplines and human and environmental needs embedded within our communities has also proven to increase interest in the STEM topics and careers, especially with populations traditionally underrepresented in these fields. Community-based learning has been widely adopted in higher education but less so in the STEM, especially engineering disciplines. This workshop will explore ways to integrate community-based learning into biomedical engineering education using successful examples as a framework and active discussions with participants to explore issues and constraints within their own classrooms. The workshop will actively engage participants in developing plans and ideas for their own students within their local community.

Workshop Organizers: Jeffrey A. Weiss, University of Utah (point of contact); Gerard Ateshian, Columbia University; Steve Maas, University of Utah

Workshop Description: FEBio is a nonlinear finite element software suite that is specifically designed for applications in biomechanics and biophysics (www.febio.org). FEBio uses the finite element method to discretize the equations for conservation of mass, linear momentum, and charge. The resulting equations allow fully coupled simulation of solid mechanics, solid-fluid mixtures, fluid mechanics, fluid-solid interactions, transport, reaction and diffusion of neutral and charged species, contact, prestrain, growth and remodeling. The governing equations are formulated based on mixture theory. It offers modeling scenarios, constitutive models and boundary conditions that are relevant to many research areas in biomechanics. All features can be used together seamlessly, giving the user a powerful tool for solving 3D problems in computational biomechanics. The software is open-source, and pre-compiled executables for Windows, Mac OS X and Linux platforms are available. There are over 8,000 registered users of the FEBio software suite.
This workshop will provide a brief overview of the FEBio project, followed by presentation and demonstration of new capabilities in the software that have been added over the last two years. This will include computational fluid dynamics analysis, fluid-solid interactions, parameter optimization, and applications of the plugin framework. Following the presentations and demonstrations, we will moderate an open question-and-answer period for users and potential users.

Workshop speakers: Jeff Weiss and Gerard Ateshian. The format will be lectures with Q&A and software demonstrations by the speakers.